The use case refers to the handling of general cargo freights by means of AGVs in a seaport terminal. A VR simulated environment reproducing a real terminal of the Livorno’s seaport will be implemented for shuttling cargo freights between the terminal reception area, the storage and the loading place in front of the ship. A virtual model of AGV will be managed and guided using a dedicated mission/navigation system. The latter will use the position information provided by the 5G network to determine the next moves on the planned path.